NOVEL CLOSTRIDIUM DIFFICILE ANTI-TOXIN (TCDA AND TCDB) HUMANIZED MONOCLONAL ANTIBODIES DEMONSTRATE IN VITRO NEUTRALIZATION ACROSS A BROAD SPECTRUM OF CLINICAL STRAINS AND IN VIVO POTENCY IN A HAMSTER SPORE CHALLENGE MODEL.

Clostridium difficile (C.difficile) infection (CDI) is the main cause of nosocomial antibiotic-associated colitis and increased incidence of community-associated diarrhea in industrialized countries.At present, the primary treatment of CDI is antibiotic administration, which is effective but often associated with recurrence, especially in the elder

The present commentary is based on the following considerations: 1) for the purposes of authorisation, a distinction is drawn between "research" and "intervention".The procedures for authorising the former are more complex, the relevant controls are stricter and approval has to be granted by a Research Ethics Committee (REC); 2) although the debate

Over the past two decades, computer-aided detection and diagnosis have emerged as a field of research.The primary goal is to enhance the diagnostic and treatment procedures for radiologists and clinicians in medical image analysis.With the help of big data and advanced artificial intelligence (AI) technologies, such as machine learning and deep lea

We investigated whole-plant leaf area in relation to ontogenetic variation in leaf-size for a forest perennial herb, Cardiocrinum cordatum.The 200-fold ontogenetic variability in C.cordatum leaf area followed a power-law dependence Plants Standard on total leaf number, a measure of developmental stage.When we normalized for plant size, the function